Medicinal Chemistry: An Introduction [Paperback]
Author: Amazon Prime Sign in to turn on 1-Click ordering | Language: English | ISBN: 0470025980 | Format: PDF, EPUB
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Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth.
From the reviews of the First Edition:
"It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION
"Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS
- Paperback: 646 pages
- Publisher: Wiley-Interscience; 2 edition (January 22, 2008)
- Language: English
- ISBN-10: 0470025980
- ISBN-13: 978-0470025987
- Product Dimensions: 9.5 x 7.5 x 1.6 inches
- Shipping Weight: 2.7 pounds (View shipping rates and policies)
- Amazon Best Sellers Rank: #299,076 in Books (See Top 100 in Books)
- #56 in Books > Science & Math > Chemistry > Industrial & Technical
Acknowledgements.
Abbreviations.
Chapter 1. An Introduction to Drugs, their Action and Discovery.
Chapter 2. Drug Structure and Solubility.
Chapter 3. Structure-activity and quantitative structures relationships.
Chapter 4. Computer aided drug design.
Chapter 5. Combinatorial Chemistry.
Chapter 6. Drugs from natural sources.
Chapter 7. Biological Membranes.
Chapter 8. Receptors and Messengers.
Chapter 9. Enzymes.
Chapter 10. Nucleic Acids.
Chapter 11. Pharmacokinetics.
Chapter 12. Drug metabolism.
Chapter 13. Complexes and chelating agents.
Chapter 14. Nitric oxide.
Chapter 15. An Introduction to drug and analogue synthesis.
Chapter 16. Drug Development and Production.
Selective further reading.
Answers to Questions.
Index.
As an undergraduate text for medicinal chemistry, I think this book is the best in the market. It's appropriate for students who have only had two semesters of organic chemistry. The layout is logical. Aside from chapter 7 (chelating agents), the first nine chapters are at least decent and mostly very good. Chapter 10 (nucleic acids) and 11 (nitric oxide) probably belong more in a biochem text than a med chem book. Chapter 12 (organic synthesis) is well out of the scope of this book and falls flat.By A Customer
The book has a huge number of errors. Most of which are in the chemical figures and will not bother anyone unless they like looking at structures. Some of the errors involve the mathematic equations and could cause trouble for a student who isn't paying attention.
The only major complaint I have about the book is that chapter 5 (pharmacokinetics) is almost completely devoid of units on the variables in the equations and graphs. Proper use of units would greatly help a student in learning material in this chapter.
While not perfect, this book is very good for a junior/senior upper-level chemistry course.
This textbook by Thomas is a very big disappointment to me. I am still trying to see how so little useful information can be spread over a vast 620 pages. The subtitle "An introduction" is one thing, but for the author to spend so much time discussing background without giving precise information about how the molecules act as drugs is unfortunate. In so many areas, it is just a waste of the students' time. It has poor illustrations too. The book is inexpensive, but I would rather pay more for a book that I could actually learn some interesting information about. If you wish to learn medicinal chemistry, you need a better book than this. This book give almost no insight in the strategies that a medicinal chemist actually uses to design drugs. Fortunately, there are some very good books out there today. My three favorite MedChem books are those written by: Patrick, Silverman, and Sneader....in that order. Nogrady is also a good book but it suffers from the opposite extreme that this book by Thomas does (it has too many specifics and not enough background).By bro
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