Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization [Kindle Edition]
Author: Edward Kerns | Language: English | ISBN: B00BMF33YW | Format: PDF, EPUB
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization
Download for free books Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization [Kindle Edition] for everyone book with Mediafire Link Download Link Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process.
The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.
* Serves as an essential working handbook aimed at scientists and students in medicinal chemistry
* Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies
* Discusses improvements in pharmacokinetics from a practical chemist's standpoint Books with free ebook downloads available Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization [Kindle Edition]
Download for free books Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization [Kindle Edition] for everyone book with Mediafire Link Download Link Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process.
The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.
* Serves as an essential working handbook aimed at scientists and students in medicinal chemistry
* Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies
* Discusses improvements in pharmacokinetics from a practical chemist's standpoint Books with free ebook downloads available Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization [Kindle Edition]
- File Size: 10507 KB
- Print Length: 552 pages
- Publisher: Academic Press; 1 edition (July 26, 2010)
- Sold by: Amazon Digital Services, Inc.
- Language: English
- ASIN: B00BMF33YW
- Text-to-Speech: Enabled
- Lending: Not Enabled
- Amazon Best Sellers Rank: #1,219,896 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
- #59 in Kindle Store > Kindle eBooks > Nonfiction > Science > Chemistry > Clinical
- #59 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Professional Science > Chemistry > Clinical
I have spent some of the last two days reading this book and I am very impressed with it. It is destined to become an authoritative text on the whole topic area of drug-like molecules and ADME screening. The chapters are well written and include sufficient detail and references so that the reader can make use of the information effectively. The book could be used in a graduate-level course for medicinal chemists or DMPK scientists.By Walter Korfmacher
The book would also be very helpful for scientists working in one area of DMPK who wish to become DMPK project managers and need to increase their understanding of other areas of DMPK that are outside of their own specific expetise function. The chapter on pharmacokinetics was well written and provides a very good overview of the topic. Overall, I can state that this book is well worth the purchase price.
This is quite simply a very impressive text and was great from the first to the last page. The introductory chapters adequately acquaint(or re-acquaint) the reader with concepts of drug-likeness and barriers to a successful drug. Topics covered in the intro chapters are then explained in great detail in individual chapters making the text very easy to follow and extremely informative. The later portion of the book describes methods used to assay and/or solve particular ADME/Tox issues and isn't necessarily useful to the non-practitioner but is definitely a go-to source if one needs this information. Also noteworthy are the problems at the end of each chapter that do a fairly good job of summarizing and applying the key topics learned in the chapter and answers are included in the appendix for reference. Overall this is a great book and would be especially useful for organic/medicinal chemistry doctoral/post-doctoral students.By Eric Ballard
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