Design and Analysis of Non-Inferiority Trials

Design and Analysis of Non-Inferiority Trials (Chapman & Hall/CRC Biostatistics Series) [Hardcover]

Author: Mark D. Rothmann Brian L. Wiens Ivan S.F. Chan | Language: English | ISBN: 1584888040 | Format: PDF, EPUB

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Design and Analysis of Non-Inferiority Trials
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The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Each chapter begins with a non-technical introduction, making the text easily understood by those without prior knowledge of this type of trial.

Topics covered include:

• A variety of issues of non-inferiority trials, including multiple comparisons, missing data, analysis population, the use of safety margins, the internal consistency of non-inferiority inference, the use of surrogate endpoints, trial monitoring, and equivalence trials
• Specific issues and analysis methods when the data are binary, continuous, and time-to-event
• The history of non-inferiority trials and the design and conduct considerations for a non-inferiority trial
• The strength of evidence of an efficacy finding and how to evaluate the effect size of an active control therapy

A comprehensive discussion on the purpose and issues involved with non-inferiority trials, Design and Analysis of Non-inferiority Trials will assist current and future scientists and statisticians on the optimal design of non-inferiority trials and in assessing the quality of non-inferiority comparisons done in practice.

Download latest books on mediafire and other links compilation Design and Analysis of Non-Inferiority Trials (Chapman & Hall/CRC Biostatistics Series) [Hardcover]

• Series: Chapman & Hall/CRC Biostatistics Series (Book 43)
• Hardcover: 454 pages
• Publisher: Chapman and Hall/CRC; 1 edition (July 12, 2011)
• Language: English
• ISBN-10: 1584888040
• ISBN-13: 978-1584888048
• Product Dimensions: 1.1 x 6 x 9.2 inches
• Shipping Weight: 1.9 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #1,185,828 in Books (See Top 100 in Books)

Note that not all Kindle readers support loading this book - for example it will not load into my Kindle Touch nor can it be read with the Kindle Cloud Reader (e.g. in a browser window). In addition, at least when read on an iPad or a Mac, there are certain symbols which are not rendered (a blank appears) making it difficult to make sense of some formulas.

I cannot believe that even after over 2 years and the issue being brought to the attention of the publishers at convention booths that this has still not been fixed! Not having all symbols rendered correctly is rather critical in mathematical technical books.

By J. P. Miller

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