The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine [Kindle Edition]
Author: John E. Lesch | Language: English | ISBN: B000YIYMRK | Format: PDF, EPUB
The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine
Download books file now The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine [Kindle Edition] for everyone book with Mediafire Link Download Link In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research. Direct download links available for The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine
Download books file now The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine [Kindle Edition] for everyone book with Mediafire Link Download Link In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research. Direct download links available for The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine
- File Size: 4501 KB
- Print Length: 376 pages
- Publisher: Oxford University Press, USA; 1 edition (September 28, 2006)
- Sold by: Amazon Digital Services, Inc.
- Language: English
- ASIN: B000YIYMRK
- Text-to-Speech: Enabled
- Lending: Enabled
- Amazon Best Sellers Rank: #879,848 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
Jack Lesch worked for years on this book and it shows. It is thoroughly researched and well written. It is not for the casual reader, however. You must be interested in the history of medicine, pharmacy, or science, and have some knowledge of those topics. If you want to understand the discovery and development of the sulfa drugs (and their play in the history of anti-microbials),this is the book for you.By Amazon Customer
An indispensable resource for anyone interested in early drug development and the dawn of pharmaceutical antibiosis. Notably Dr. Lesch has provided important insights into the seminal European development and investigation of sulfanilamide, the world's first widely distributed antibiotic. Lesch has thoroughly mined both the relevant corporate (Bayer) and academic (Pasteur Institute) archives to paint a much fuller and more nuanced picture of the collaborative and competitive scientific work that ultimately revolutionized the global practice of medicine. --Barbara J. Martin, MD, author, Elixir: The American Tragedy of a Deadly DrugBy B. Martin
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