Absorption and Drug Development

Absorption and Drug Development: Solubility, Permeability, and Charge State [Hardcover]

Author: Alex Avdeef | Language: English | ISBN: 0471423653 | Format: PDF, EPUB

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Absorption and Drug Development: Solubility, Permeability, and Charge State
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Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules:

• Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.
• Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.

Direct download links available for Absorption and Drug Development: Solubility, Permeability, and Charge State

• Hardcover: 312 pages
• Publisher: Wiley-Interscience; 1 edition (August 21, 2003)
• Language: English
• ISBN-10: 0471423653
• ISBN-13: 978-0471423652
• Product Dimensions: 9.4 x 6.3 x 0.8 inches
• Shipping Weight: 1 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #3,480,389 in Books (See Top 100 in Books)

Preface.

Acknowledgments.

Definitions.

1. Introduction.

2. Transport Model.

3. Charge State.

4. Partitioning Into Octanol.

5. Partitioning Into Liposomes.

6. Solubility.

7. Permeability.

8. Summary and Some Simple Rules.

References.

Index.

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